New article about effect of nanoparticles on tumors
The long-term collaboration between Department of Molecular Cell Biology (Iversen/Sandvig and collaborators) and Department of Tumor Biology (Mælandsmo group) has resulted in a new article published in International Journal of Nanomedicine (impact factor 8.0). Remya Valsalakumari is the first author and Tore-Geir Iversen the last and communicating author. The data show promising results following injection of cabazitaxel-loaded polyalkyl cyanoacrylate nanoparticles in mice bearing patient derived xenografts of triple negative breast cancer. The nanoparticles gave a strong effect both on the tumor and on the tumor-associated myeloid compartment, which probably boost the anti-tumor response.
The study included contributions from scientists at SINTEF Trondheim, who manufactured the particles, and biologists in Newcastle and Salzburg. The particles used in this study were a further development of particles developed during Nanocan, a five-year national competence building project in nanomedicine (2013-2018) headed by Sandvig.
Links:
Int J Nanomedicine article:
Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants.
Valsalakumari R, Pandya AD, Prasmickaite L, Kvalvaag A, Myrann AG, Åslund AKO, Kjos MS, Fontecha-Cuenca C, Haroon HB, Ribeiro ARS, Horejs-Hoeck J, Moghimi SM, Mørch Ý, Skotland T, Sandvig K, Mælandsmo GM, Iversen TG.
Int J Nanomedicine. 2024 Mar 26;19:3009-3029. doi: 10.2147/IJN.S450283. eCollection 2024.
PMID: 38562610
Gunhild Mælandsmo's group:
Metastasis Biology and Experimental Therapeutics
Tore-Geir Iversen's project group:
Nanoparticles in Biomedicine: In vitro studies